Immunodeficiency Diseases at Stay Healthy 4Life

There are two types of immunodeficiency diseases; primary and secondary.

Primary immune deficiency, caused by a genetic problem in the body’s defense system, is when the body’s immune defense system is missing a part or does not work correctly. Over 150 different primary immune deficiency diseases are known today with some occurring with greater frequency (selective IgA deficiency) while others are extremely rare (ADA deficiency). If a primary immune deficiency is not treated, it can cause serious illness and life-threatening infections. Present day, thanks to enhanced technology, doctors can recognize primary immune deficiency signs even earlier in order people can live close to normal lives with treatment. Previously, treatment options were limited and life expectancy was shorter for some of these individuals.

Secondary immune deficiency disease is when the body’s defense system is changed due to an external factor outside the body. Some examples include dialysis, burns, chemotherapy, exposure to toxic chemicals or UV radiation or a viral, bacterial or parasitic infection.

Focus will be on primary immune deficiency disease since secondary is treated in so many different ways, depending on the external agent that enters the person’s body. Primary immune deficiency is a disorder caused by an inherited flaw in the immune system that increases the susceptibility to infections. Unlike secondary or acquired immune deficiency diseases, which are caused by infectious, chemical or radiological agents, primary immunodeficiency diseases are the result of altered or mutated genes that can be passed on from parent to child or can arise as genes are being copied. AIDS is a prototype of an acquired immune deficiency disease. It has been estimated that there are 100 different primary immunodeficiency diseases. All are genetic conditions in which specific cells of the immune system do not function properly. Clinical symptoms range from mild or nonexistent as in the case of selective IgA deficiency to severe symptoms as in the case of severe combined immunodeficiency (SCID), commonly referred to as “bubble-boy” syndrome. Although the susceptibility to infections is a major consequence of the primary immunodeficiency diseases, they may cause other health problems as well, including allergies, asthma, swollen joints, digestive tract problems, growth problems or an enlarged liver and spleen. Many people with primary immune deficiency diseases require treatment which may include intravenous gamma globulin infusions, antibiotic therapies, or bone marrow transplantation. Primary immunodeficiency diseases were once thought to be rare, mostly because only the more severe forms were recognized. Today physicians realize that they are not uncommon. They are sometimes relatively mild, and they can occur in teenagers and adults as often as in infants and children.There are over 70 different types of primary immunodeficiency diseases. Each type has somewhat different symptoms, depending on which parts of the immune defense system are deficient. Some deficiencies are deadly, while some are mild. But they all have one thing in common in that they may open the door to multiple infections.

Individuals, many of them infants and children, with primary immunodeficiency diseases get one infection after another. Ear, sinus, and other infections may not improve with treatment as expected, but keep coming back or occurring with less common but severe infections, such as recurrent pneumonia. Besides being painful, frightening, and frustrating, these constant infections can cause permanent damage to the ears or to the lungs. In the more severe forms of many of them infants and children, germs which cause only mild infections in people with healthy immune systems may cause severe or life-threatening infections. People with primary immunodeficiency diseases get infections more often, take longer to recover, even with antibiotic treatment, and are more likely to have recurring infections.

Although infections are the hallmark of primary immunodeficiency diseases, they are not always the only health problem, or even the main one. Some primary immunodeficiency diseases are associated with other immune system disorders, such as anemia, arthritis, or autoimmune diseases while others involve more than the immune system such as those that are associated with symptoms involving the heart, digestive tract, or the nervous system. Some primary immunodeficiency diseases tend to retard growth and increase the risk of cancer.

The primary immune deficiency disorders range in frequency. Some disorders such as selective IgA deficiency are quite common, occurring as often as 1/500 to 1/1000 individuals. Others disorders such as SCID are rare affecting perhaps one person per million. Approximately 25,000 to 50,000 Americans are severely affected by primary immune deficiency disorders.

Many patients with primary immune deficiency will need treatment with intravenous immunoglobulin (IVIG) and antibiotic medications. Gamma globulin is extracted from healthy people’s donation of plasma and is purified through a manufacturing process before administering. Other patients may need more invasive therapies. Click here to buy codeine from NHS Heroes to get yours today.


Getting the Permit for home Renovation

Renovating your home and giving it a new appearance can be the best way to make it look better than before. Whether you want to add extra room to your home, resize the available rooms or some other change you want to implement, you need to have thorough planning in your mind about all the changes you want to put into practice and all the things required for that. Learn more information about getting home renovation permit at

Permit for home Renovation

It is not a matter of one-day; it is a pre-planned process that takes time depending upon your requirements and list of changes. So many things need to consider before beginning home renovation and lots of planning goes into before you actually finalize your decision.

One most important thing is that you should make sure that you are not violating any rule of homeowners association with your home renovation. They have classified the renovation into various categories and for few ones you need to get the permit from the association before you start the renovation.

This is a common scenario that many people out of us don’t want to waste money on permits and can be often heard saying what is the use of permit? Or why we need it?

But they don’t understand that it is all about their safety and peace of mind while renovating the home. When you have permit in your hand you are not afraid of any association who can stop you from construction as you have approval letter from authority.

I came across one such situation when my friend started renovating his home and I visited him after few days when he started the work and I asked him that you are doing construction on the top floor and have you got the permission to do it?

He just smiled and said what that is? Then, I told him that you ought to take permission from the homeowners’ authority before doing this so that they don’t have any objection with this and to make sure that you are not violating any of their rule and you are on the safe side. Then I told him that you just need to fill the application and attach all the required documents. If everything goes well it just takes 2 weeks to get the permission and your peace of mind.

He just thanked me and applied for permit to keep him safe from any legal action and to protect him if any problem arise in future like I just forgot to explain here that if you don’t have permit then in case if in future any insurance problem persists then at that time you can’t claim for insurance when you have done the wrong thing by not getting permit for your renovation work.

One thing more is to be taken care of that you need to do the construction work as it is described in the plan that you have got permission for because the authority people can come any time to check whether the work is going on according to the layout plan.